Couples

Shorten Your Journey to Parenthood
  • Male Fertility
  • Capacitation
  • Cap-Score

A Man’s Fertility Can Now be Measured and Ranked. This New Test Has the Power to Predict Pregnancy.

Finally, there is a groundbreaking male fertility test that can shorten your journey to parenthood by quantifying a man’s fertility. In a recently completed landmark prospective study, men with a normal score on this new test had more than four times the number of pregnancies than men who scored low. This new test, Cap-Score™, is now a benchmark for measuring male fertility, and the resulting data can be used to predict a man’s probability of generating a pregnancy. A man’s fertility can now, for the first time, be measured and ranked using Cap-Score.

REVOLUTIONARY TECHNOLOGY

Cap-Score evaluates a man’s level of fertility by quantifying the number of sperm cells in the ejaculate capable of generating a pregnancy. It measures the fundamental biological process that controls fertility and does so by proprietary technology that assesses the sperm’s capacity to fertilize an egg.

The revolutionary Cap-Score technology analyzes sperm on the molecular level. It calculates the percent of sperm cells in the ejaculate capable of fertilizing the egg. Cap-Score is the only test that can predict the man’s ability to generate a pregnancy.

Cap-Score detects and analyzes localization patterns using fluorescent microscopy to distinguish fertile from infertile sperm cells, and those capable of going on to generate a pregnancy from those that cannot.

“We now have a tool to properly assess male fertility. We no longer need to rely solely on a semen analysis. The addition of Cap-Score to the clinical evaluation of male fertility offers a functional measure that will help clinicians better counsel couples on how much intervention may or may not be needed,” said Eric Seaman, MD, of New Jersey Urology, a leading practitioner of male reproductive medicine.

PROVIDING INSIGHT FOR MILLIONS OF MEN AND COUPLES

The results from this proprietary male fertility test provide answers for many couples struggling to conceive and become pregnant. Of the millions of men seeking assistance for infertility each year, remarkably, more than 50% are diagnosed as unexplained by current, inadequate methods. Cap-Score’s ability to quantify a man’s probability to generate a pregnancy will help clinicians counsel couples with personalized guidance to shorten their journey to parenthood saving time, emotional distress and money.

Data released by the CDC in 2017, showed for the first time, women aged 30-34 were having more babies than women aged 25-29. The trend is clear that couples are waiting longer to start a family. But that doesn’t mean you should wait to get a Cap-Score. Starting early can inform you as to how easy or difficult the path to parenthood will be. Couples will then have time to better manage their journey by starting sooner or seeking advice from a trusted healthcare professional. If the Cap-Score is normal, you will know the man’s fertility should not be an issue and can plan accordingly.

Whether the couple has decided to delay parenthood or the man is diagnosed with male factor infertility, Cap-Score can assist the couple and the clinician in achieving pregnancy.

SHIFTING THE FOCUS TO UNDERSTAND MALE FERTILITY

Cap-Score represents a breakthrough technology that has shifted the focus of understanding a man’s fertility from descriptive measures found with a semen analysis to a functional measure that analyzes the biological process within the sperm cell controlling fertilization. This biological process, known as capacitation, cannot be measured by a semen analysis, but can be quantified by Cap-Score. Data shows that Cap-Score is the best predictor of a man’s fertility.

Cap-Score Can Shorten Your Journey to Parenthood

Cap-Score is a new and revolutionary technology you can now use to help guide you on your path to parenthood. It’s like a compass, pointing you in the right direction. Cap-Score helps you to take the most effective path, with the least amount of obstacles, on your journey to parenthood.

Capacitation is the process sperm must undergo to become able to fertilize an egg. Inside the female tract, the membranes of capacitating sperm undergo several changes that allow sperm to:

  • Start a hyperactivated swimming pattern so it has the ability to move through the Fallopian tube and through the external covering of the egg.
  • Undergo a process in which enzymes are released that enable the sperm to pass between the cells surrounding the egg, and interact with the external covering of the egg.

The changes that occur as a result of capacitation collectively enable the sperm to fertilize the egg. If capacitation does not occur, the sperm cannot fertilize. While other male fertility tests measure sperm concentration, motility and morphology, the Cap-Score™ Assay is groundbreaking in that we believe it is the only test developed to help determine if the sperm is able to fertilize an egg. By developing a way to measure sperm’s ability to capacitate, Androvia hopes to help couples find the right fertility solution for them.

Capacitation may be a factor in up to half of male infertility cases.

Learn more about the Cap-Score™ test

The Cap-Score™ Assay, allows couples and their physicians to evaluate the sperm’s ability to capacitate – a critical measure of male fertility. Capacitation is the process sperm must undergo to become able to fertilize an egg. When it comes to conception, your Cap-Score™ counts.

The Cap-Score Assay is a laboratory-developed test capable of determining whether sperm can actually fertilize an egg. Knowing and understanding their Cap-Score will help couples make informed decisions with their physicians about the fertility solution that is best suited for them.

CAP-SCORE: A MORE COMPLETE PICTURE

The Cap-Score Assay is the missing component to a truly comprehensive semen analysis. Previously, physicians were only able to test sperm concentration, motility and morphology to determine a man’s fertility. The Cap-Score Assay measures sperm function and is the first test of its kind. It is designed to complement clinical evaluations of the male and female partners, including traditional semen analysis. By offering information specific to sperm function and fertilization potential, Cap-Score provides physicians and couples the information necessary to make more informed decisions about the best options for conceiving.1,2

The Cap-Score Assay can also assist in determining the success of vasectomy reversals and varicocele procedures that are conducted to restore fertility, as well as provide a mechanism for evaluating the effectiveness of supplements and other techniques used to boost fertility.

CAP-SCORE: INTERPRETING THE RESULTS

Cap-Score provides an assessment of the fertilizing ability of a man’s sperm over a fixed period of time. The Cap-Score Assay should not be the singular test administered and/or considered when evaluating the fertility status of the male partner. Studies demonstrate that, in general, men with Cap-Scores in the normal range have sperm that exhibit functional competency. Conversely, Cap-Scores in the abnormal range indicate a degree of potential infertility. For a couple who is seeking to understand their fertility, their physician will evaluate the man’s Cap-Score in conjunction with a semen analysis as well as a complete medical work-up inclusive of both the male and female partners. For example, a physician may have a different recommendation for two men with the same Cap-Score because of differing sperm counts and/or motilities. Each component plays a role and together can determine your total fertility.

The Cap-Score Assay provides an assessment of the fertilizing ability of the man’s sperm. The test provides an analysis of sperm on a molecular level to determine the percentage of sperm capable of undergoing capacitation. Cap-Score results should be interpreted in the context of a semen analysis as well as a complete medical work-up of both the male and female partners.

CAP-SCORE: CLARIFYING A COUPLE’S CHOICES

Studies highlight that couples in which the man has a normal Cap-Score may be recommended to continue or may be candidates for less invasive methods, such as an intrauterine insemination (IUI). Conversely, couples in which the man has an abnormal Cap-Score may be recommended, from the start, to pursue approaches such as in-vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI), saving time and reducing stress.

When the physician knows a couple’s Cap-Score, the physician now has more information and a clearer understanding of what assisted reproductive techniques might best help that couple conceive.

Because many factors can impact sperm function, physicians may consider retesting in three months and/or in conjunction with a repeat semen analysis.

Order Your Cap-Score Kit


1Franken, DR, Oehninger, S, Semen Analysis and Sperm Function Testing, Asian J Androl. 2012 Jan; 14(1): 6–13. Published online 2011 Dec 19. doi: 10.1038/aja.2011.58

2Oehninger, Sergio; Franken, DR; Ombelet, Willem, Sperm functional tests, Fertility and Sterility, Vol 102, No. 6, December 2014, Pages 1528–1533 http://www.ncbi.nlm.nih.gov/pubmed/25450304



Engineering scientific technology for
the global advancement of male fertility.





Engineering scientific technology for the global advancement of male fertility.




Copyright by Androvia Lifesciences 2020. All rights reserved.


Copyright by Androvia Lifesciences 2020. All rights reserved.