Scientific Data and Presentations

Company announcements:

Press Release: Prospective study demonstrates that men who had a normal score on a new fertility test, Cap-Score™, had a fourfold increase in pregnancies during the first attempt compared to men with a low score.
Published Manuscript: Cap-Score™ prospectively predicts probability of pregnancy. Mol. Reprod Dev. 2018; 1-11.  https://doi.org/10.1002/mrd.23057

Press Release: Study shows that altering insemination timing can improve a couple’s ability to conceive, either naturally or through assisted reproduction.
Published Manuscript: Timing of sperm capacitation varies reproducibly among men. Mol. Reprod Dev. 2018; 1-10.  https://doi.org/10.1002/mrd.22972

Press Release: Study projects the clinical impact of the Cap-Score™ by improving pregnancy rates and saving couples time and money.
Published Manuscript: Projecting the potential impact of the Cap-Score™ on clinical pregnancy, live births, and medical costs in couples with unexplained infertility. J Assist Reprod Genet (2017). https://doi.org/10.1007/s10815-017-1021-4

Press Release: Studies validate the clinical utility of the Cap-Score™.
Published Manuscript: Localization patterns of the ganglioside GM1 in human sperm are indicative of male fertility and independent of traditional semen measuresMol Reprod Dev201784:423435. https://doi.org/10.1002/mrd.22803
Published Manuscript: Validation of a laboratory-developed test of human sperm capacitation. Mol Reprod Dev201784:408-422.  
https://doi.org/10.1002/mrd.22801


Data presented at past scientific meetings:

ASRM: American Society for Reproductive Medicine
October 12-16, 2019; Philadelphia, PA

  • A multicentric, prospective test of Cap-Score™’s ability to predict a man’s probability of generating pregnancy
    Understanding the data

  • Defects in sperm capacitation and fertilizing ability are highly prevalent in men undergoing fertility examination, even if normozoospermic
    Understanding the data
  • Impacts of TEST (TES and Tris) yolk buffer and cooling on the ability of human sperm to capacitate

ESHRE: European Society of Human Reproduction and Embryology
June 23-26, 2019; Philadelphia, PA

  • Cap-Score ™ accurately predicts probability of generating pregnancy across maternal age stratifications


ASA: American Society for Andrology
April 21-24, 2018; Portland, OR

  • The association of Cap-Score ™ and pregnancy initiation
  • Timing of sperm capacitation varies among men and is consistent within men
  • Case Report: Varicocelectomy improves semen quality and the ability of sperm to undergo capacitation

ASA: American Society of Andrology
April 22-25, 2017; Miami, FL

  • Localization patterns of the ganglioside GM1 identify sperm capable of undergoing capacitation and acrosome exocytosis

ASRM: American Society of Reproductive Medicine
October 15-19, 2016; Salt Lake City, UT

  • Capacitation defects are common in men questioning their fertility and are independent of standard semen analysis parameters
    clinical-cohort-study-9-19-16
  • Capacitation timing varies among men, but is consistent among ejaculates within individuals
    cap-rate-asrm-2016-poster

AUA: American Urological Association + SSMR Annual Meeting: Society for the Study of Male Reproduction
May 6-10, 2016; San Diego, CA

  • Impacts of common semen handling methods on sperm function
    Slide1

ASA: American Society of Andrology
April 2-5, 2016; New Orleans, LA

  • Consistent differences among men in capacitation timing could personalize IUI/ART
    Slide1
  • Normal ejaculates, as defined by WHO, can have abnormal capacitation ability
    Slide1
  • Sperm from fertile men and those seeking fertility exams differ in their ability to capacitate
    Slide1
  • Reliability estimates for a test of sperm capacitation, a functional complement to semen analysis
    Slide1

# # #

A New Test for Male Infertility is on the Horizon: The Androvia Cap-Score

Male Fertility Doc, January 27, 2016
Coming soon, a company named Androvia will be releasing a new test that assesses the fertilizing ability of a man’s sperm.  Prior to fertilization, an individual sperm must complete three tasks: “capacitation”, “hyperactivation” and the “acrosome reaction”.  Androvia uses technology that identifies the ability of sperm to undergo capacitation.